- at DynaMo Center of Excellence

Are you interested in performing research within protein-protein interactions? And are you looking for a project in a scientific stimulating environment? If yes, we might have the right project for you.

DynaMo – the research group

DynaMo - Danish National Research Foundation Center of Excellence for Dynamic Molecular Interactions - was established in January 2012. We use glucosinolate biosynthesis in Arabidopsis thaliana as a model pathway to study biological phenomena.

At DynaMo we offer you an active and international study environment including weekly group meetings and access to our international seminar series with invited speakers leading in their field. In return we expect that you display your full potential through strong drive and discipline throughout the research project. You will be an integrated part of the Center. Both Danish and foreign students are encouraged to apply.

Find out more about DynaMo at http://dynamo.ku.dk

About the project

The cell is a busy place, where supramolecular machines facilitate a diversity of biological tasks. How these machines are assembled within the crowded cellular milieu – where the likelihood of random encounters is low – and how the cellular components are able to find their way to the final destination are central questions in biological sciences. There is an increasing awareness that we have to think in terms of the interactomes as opposed to the classical one-protein-at-a-time approach.

To study pathway-specific supramolecular complexes, we use the model plant Arabidopsis and its primary defense compounds, glucosinolates, which is a powerful model system with extensive ‘omics tools available. The project employs targeted and untargeted state-of-the-art protein-protein interaction methodologies to test for interaction between known enzymes and to identify novel interacting proteins. The most promising interactions will be confirmed by pulldown or co-immunoprecipitation assays from plant tissues. Additionally, advanced bioimaging technology will be used for in vivo validation.

Methods – what you can learn

We expect to gain basic knowledge about the mechanism underlying the dynamics of assembly of multi-protein complexes. The project will allow you to learn and use a diverse array of techniques in a stimulating environment.

Contact persons:

Associate Professor Meike Burow
Professor Barbara Halkier

Application

Your application must include:

• Motivational letter
• Preferred choice of research topic
• CV
• Grade transcript

Please email your application to (subject: Master project application).